RP˗HPLC a valuable tool in monitoring dissolution test of fixed combination dosage forms
نویسندگان
چکیده
منابع مشابه
A Green Potentiometric Application for Selective Monitoring of Doxylamine Succinate Dissolution Profile in Combined Dosage Form
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متن کامل"In vitro" dissolution tests for solid oral dosage forms.
©2010 Particle Sciences, Inc. All rights reserved. the drug substance and involves two steps: dissolution and absorption (or permeability). Understanding the multi-step dissolution process is essential to proper in vitro method development. Dissolution is the process of extracting the API out of the dosage form solid-state matrix into solution within the gastrointestinal tract. Absorption is th...
متن کاملComparison of Drug Release From Metoprolol Modified Release Dosage Forms in Single Buffer versus a pH-Gradient Dissolution Test
Introduction Metoprolol is a cardioselective beta blocker that has been classified as a class I substance according to the Biopharmaceutics Classification Scheme BCS [1], meaning that it is highly soluble and highly permeable. The drug is readily and completely absorbed throughout the whole intestinal tract [2-4] but is subject to extensive firstpass metabolism resulting in incomplete bioavaila...
متن کاملDevelopment and Validation of a Dissolution Test with Reversed-phase Liquid Chromatography Analysis for Rupatadine in Tablet Dosage Forms
A dissolution test for in vitro evaluation of tablet dosage forms containing 10 mg of rupatadine was developed and validated by RP-LC. A discriminatory dissolution method was established using apparatus paddle at a stirring rate of 50 rpm with 900 mL of deaerated 0.01 M hydrochloric acid. The proposed method was validated yielding acceptable results for the parameters evaluated, and was applied...
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ژورنال
عنوان ژورنال: Supplement 1
سال: 2020
ISSN: 1857-8969,1409-8695
DOI: 10.33320/maced.pharm.bull.2020.66.03.076